Pain is a common and complex problem. While acute pain is related to tissue injury and can be a protective mechanism, chronic pain is more challenging and it is no longer considered by health care professionals a symptom but a disease in itself. Medical care, physical therapy, chiropractic adjustments, acupuncture treatments, and psychotherapy could contribute to the treatment of pain. Dietary supplements, a well-balanced diet, and lifestyle changes should also be considered as part of the program. It is well known that some compounds found in supplements could play a significant role in long term management of a variety of chronic pain conditions.